Disable Desktop Network Manager configuration :

sudo stop network-manager
echo "manual" | sudo tee /etc/init/network-manager.override

Disable resolvconf auto DNS conf. service :

cp /etc/resolv.conf /tmp/resolv.conf
rm resolv.conf # delete the symlink to resolvconf
mv /tmp/resolv.conf /etc/

Example of manual configuration :

/etc/network/interfaces :

auto eth0
iface eth0 inet static
address 10.0.1.253
netmask 255.255.255.0

/etc/resolv.conf :

search mylan.net
nameserver 8.8.8.8

Re-enable resolvconf auto DNS conf service (if you change your mind) :

sudo dpkg-reconfigure resolvconf # answer YES to enable dynamic updates

Additional tags : resolvconf, config